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Article

Drosophila's insulin/PI3-kinase pathway coordinates cellular metabolism with nutritional conditions.

Developmental cell - 1 Feb 2002

Britton Jessica S, Lockwood Wendy K, Li Ling, Cohen Stephen M, Edgar Bruce A

Abstract excerpt

Studies in Drosophila have characterized insulin receptor/phosphoinositide 3-kinase (Inr/PI3K) signaling as a potent regulator of cell growth, but its function during development has remained uncertain. Here we show that inhibiting Inr/PI3K signaling phenocopies the cellular and organismal effects of starvation, whereas activating this pathway bypasses the nutritional requirement for cell growth, causing...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 11832249
DOI: 10.1016/s1534-5807(02)00117-x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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