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Article

Phosphorylation of MCAD selectively rescues PINK1 deficiencies in behavior and metabolism.

Molecular biology of the cell - 15 May 2018

Course Meredith M, Scott Anna I, Schoor Carmen, Hsieh Chung-Han, Papakyrikos Amanda M, Winter Dominic, Cowan Tina M, Wang Xinnan

Abstract excerpt

PTEN-induced putative kinase 1 (PINK1) is a mitochondria-targeted kinase whose mutations are a cause of Parkinson's disease. We set out to better understand PINK1's effects on mitochondrial proteins in vivo. Using an unbiased phosphoproteomic screen in Drosophila, we found that PINK1 mediates the phosphorylation of MCAD, a mitochondrial matrix protein critical to fatty acid metabolism. By mimicking...

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Identifiers

PMID: 29563254
DOI: 10.1091/mbc.E18-03-0155
PMCID: PMC5935071

Genes

PINK1
PTEN

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

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