Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Cancer, type 2 diabetes, and ageing: news from flies and worms.

Swiss medical weekly - 18 Dec 2004

Hafen E

Abstract excerpt

The tumour suppressor gene PTEN is, next to p53, the second most frequently mutated gene in human cancers. The genes TSC1 and TSC2 are mutated in the severe human syndrome called Tuberous Sclerosis. Patients with this disease have large benign tumours composed of large cells in the brain. The gen...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Aging
Share to Caenorhabditis elegans
Share to Cell Physiological Phenomena

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Diabetes Mellitus, Type 2

Share to Drosophila

Share to Genes, Tumor Suppressor

Share to Growth

Share to Tuberous Sclerosis

Source

Identifiers

PMID: 15635489
DOI: 10.4414/smw.2004.09885

Genes

PTEN
TSC1
TSC2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026. Prepared record publication-15635489-2026-09-01.1. Manifest publication-graph-cohort-2026-09-01.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 1 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Cancer, type 2 diabetes, and ageing: news from flies and worms.PMID 15635489Read ↗

Separating cause from effect: how does insulin/IGF signalling control lifespan in worms, flies and mice?Semantic proximity Read ↗

Metabolic regulation of lifespan from a C. elegans perspectiveSemantic proximity Read ↗

The human tumour suppressor PTEN regulates longevity and dauer formation in Caenorhabditis elegans.Semantic proximity Read ↗

Insulin-like growth factors and aging: lessons from Laron syndromeSemantic proximity Read ↗

Early life starvation and Hedgehog-related signaling activate innate immunity downstream of daf-18/PTEN and lin-35/Rb causing developmental abnormalities in adult C. elegansSemantic proximity Read ↗

The first long-lived mutants: discovery of the insulin/IGF-1 pathway for ageing.Semantic proximity Read ↗

Regulation of the insulin-like developmental pathway of Caenorhabditis elegans by a homolog of the PTEN tumor suppressor gene.Semantic proximity Read ↗

Insulin/IGF-I-signaling pathway: an evolutionarily conserved mechanism of longevity from yeast to humansSemantic proximity Read ↗

Single-gene mutations and healthy ageing in mammals.Semantic proximity Read ↗

mTOR and Aging: An Old Fashioned DressSemantic proximity Read ↗

The role of insulin/IGF-1 signaling in the longevity of model invertebrates, C. elegans and D. melanogasterSemantic proximity Read ↗

IGF-1 signaling and aging.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.