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Article

PINK1-mediated phosphorylation of Miro inhibits synaptic growth and protects dopaminergic neurons in Drosophila.

Scientific reports - 7 Nov 2014

Tsai Pei-I, Course Meredith M, Lovas Jonathan R, Hsieh Chung-Han, Babic Milos, Zinsmaier Konrad E, Wang Xinnan

Abstract excerpt

Mutations in the mitochondrial Ser/Thr kinase PINK1 cause Parkinson's disease. One of the substrates of PINK1 is the outer mitochondrial membrane protein Miro, which regulates mitochondrial transport. In this study, we uncovered novel physiological functions of PINK1-mediated phosphorylation of Miro, using Drosophila as a model. We replaced endogenous Drosophila Miro (DMiro) with transgenically expressed...

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Identifiers

PMID: 25376463
DOI: 10.1038/srep06962
PMCID: PMC4223694

Genes

PINK1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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PINK1-mediated phosphorylation of Miro inhibits synaptic growth and protects dopaminergic neurons in Drosophila.PMID 25376463Read ↗

Parkinson's Disease–Associated Kinase PINK1 Regulates Miro Protein Level and Axonal Transport of MitochondriaSemantic proximity Read ↗

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Miro phosphorylation sites regulate Parkin recruitment and mitochondrial motility.Semantic proximity Read ↗

PINK1-dependent phosphorylation of PINK1 and Parkin is essential for mitochondrial quality control.Semantic proximity Read ↗

PINK1 and Parkin Target Miro for Phosphorylation and Degradation to Arrest Mitochondrial MotilitySemantic proximity Read ↗

Phosphorylation of MCAD selectively rescues PINK1 deficiencies in behavior and metabolism.Semantic proximity Read ↗

Functional Impairment in Miro Degradation and Mitophagy Is a Shared Feature in Familial and Sporadic Parkinson's Disease.Semantic proximity Read ↗

Endoplasmic Reticulum Proteins Impact Penetrance in a <i>Pink1</i>-Mutant <i>Drosophila</i> ModelSemantic proximity Read ↗

The GTPase dMiro is required for axonal transport of mitochondria to Drosophila synapses.Semantic proximity Read ↗

Parkinson's disease mutations in PINK1 result in decreased Complex I activity and deficient synaptic function.Semantic proximity Read ↗

Characterization of PINK1 (PTEN-induced putative kinase 1) mutations associated with Parkinson disease in mammalian cells and Drosophila.Semantic proximity Read ↗

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