Article

Loss of PINK1 promotes the expansion of hematopoietic cells via upregulating autophagy

2023-04-10

Abstract excerpt

PTEN-induced putative kinase 1 (PINK1) is a well-characterized regulator of mitochondrial quality control through mitophagy and its mutations are associated with recessive Parkinson’s disease. However, little is known about its functions in normal and malignant hematopoiesis in vertebrates. Here we aim to unravel the roles of PINK1 in definitive hematopoiesis and its underlying mechanisms using zebrafish (Danio re...

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Literature Corpus work: 9a2538c7-58a1-5435-bd12-b8dd9919a9f6
DOI: 10.21203/rs.3.rs-2671385/v1

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