Article
Gating modes of calcium-activated chloride channels TMEM16A and TMEM16B.
The Journal of physiology - 15 Dec 2015
Cruz-Rangel Silvia, De Jesús-Pérez José J, Contreras-Vite Juan A, Pérez-Cornejo Patricia, Hartzell H Criss, Arreola Jorge
Abstract excerpt
KEY POINTS: Calcium-activated chloride channels TMEM16A and TMEM16B support important physiological processes such as fast block of polyspermy, fluid secretion, control of blood pressure and sensory transduction. Given the physiological importance of TMEM16 channels, it is important to study how incoming stimuli activate these channels. Here we study how channels open and close and how the process of gating is...
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