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Article

Independent activation of distinct pores in dimeric TMEM16A channels.

The Journal of general physiology - 1 Nov 2016

Jeng Grace, Aggarwal Muskaan, Yu Wei-Ping, Chen Tsung-Yu

Abstract excerpt

The TMEM16 family encompasses Ca2+-activated Cl- channels (CaCCs) and lipid scramblases. These proteins are formed by two identical subunits, as confirmed by the recently solved crystal structure of a TMEM16 lipid scramblase. However, the high-resolution structure did not provide definitive information regarding the pore architecture of the TMEM16 channels. In this study, we express TMEM16A channels constituting...

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PMID: 27799319
DOI: 10.1085/jgp.201611651
PMCID: PMC5089935

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Independent activation of distinct pores in dimeric TMEM16A channels.PMID 27799319Read ↗

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