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Article

Membrane localization and function of Vav3 in T cells depend on its association with the adapter SLP-76.

The Journal of biological chemistry - 15 Apr 2005

Charvet Céline, Canonigo Ann Janette, Billadeau Daniel D, Altman Amnon

Abstract excerpt

The Vav family of guanine exchange factors plays a critical role in lymphocyte proliferation, cytoskeletal reorganization, and gene transcription upon immunoreceptor engagement. Although the role of Vav1 in T cells is well documented, the role of Vav3 is less clear. We investigated the subcellular localization of Vav3 during T cell activation. We report here that phosphorylation of Vav3 on tyrosine residue...

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PMID: 15708849
DOI: 10.1074/jbc.M500275200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Membrane localization and function of Vav3 in T cells depend on its association with the adapter SLP-76.PMID 15708849Read ↗

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