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Article

Divalent Cation Modulation of Ion Permeation in TMEM16 Proteins.

International journal of molecular sciences - 23 Feb 2021

Nguyen Dung M, Kwon Hwoi Chan, Chen Tsung-Yu

Abstract excerpt

Intracellular divalent cations control the molecular function of transmembrane protein 16 (TMEM16) family members. Both anion channels (such as TMEM16A) and phospholipid scramblases (such as TMEM16F) in this family are activated by intracellular Ca2+ in the low µM range. In addition, intracellular Ca2+ or Co2+ at mM concentrations have been shown to further potentiate the saturated Ca2+-activated current of...

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Identifiers

PMID: 33672260
DOI: 10.3390/ijms22042209
PMCID: PMC7926781

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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