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Article

Exploiting Drug Addiction Mechanisms to Select against MAPKi-Resistant Melanoma

18 Sept 2017

Abstract excerpt

Abstract Melanoma resistant to MAPK inhibitors (MAPKi) displays loss of fitness upon experimental MAPKi withdrawal and, clinically, may be resensitized to MAPKi therapy after a drug holiday. Here, we uncovered and therapeutically exploited the mechanisms of MAPKi addiction in MAPKi-resistant BRAFMUT or NRASMUT melanoma. MAPKi-addiction phenotypes evident upon drug withdrawal spanned transient cell-cycle slowdown...

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Identifiers

PMID: 28923912
DOI: 10.1158/2159-8290.cd-17-0682

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