Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Phenotypic tumour cell plasticity as a resistance mechanism and therapeutic target in melanoma.

European journal of cancer (Oxford, England : 1990) - 1 May 2016

Roesch Alexander, Paschen Annette, Landsberg Jenny, Helfrich Iris, Becker Jürgen C, Schadendorf Dirk

Abstract excerpt

Despite the recent success of MAPK and immune checkpoint inhibitors in advanced melanoma, intrinsic and acquired resistance mechanisms determine the efficacy of these therapeutic approaches. Therapy resistance in melanoma is not solely driven by genetic evolution, but also by epigenetically driven adaptive plasticity. Melanoma cells are shifting between different transcriptional programs, cell cycle states and...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Drug Resistance, Neoplasm
Share to Epithelial-Mesenchymal Transition

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Melanoma

Share to Molecular Targeted Therapy

Share to Neoplastic Stem Cells

Share to Phenotype

Share to Tumor Escape

Share to Tumor Microenvironment

Source

Identifiers

PMID: 27023049
DOI: 10.1016/j.ejca.2016.02.023

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Phenotypic tumour cell plasticity as a resistance mechanism and therapeutic target in melanoma.PMID 27023049Read ↗

Phenotype Switching and the Melanoma Microenvironment; Impact on Immunotherapy and Drug Resistance.Semantic proximity Read ↗

Understanding Molecular Mechanisms of Phenotype Switching and Crosstalk with TME to Reveal New Vulnerabilities of Melanoma.Semantic proximity Read ↗

Exploring the Complex and Multifaceted Interplay between Melanoma Cells and the Tumor MicroenvironmentSemantic proximity Read ↗

Cancer Cell Phenotype Plasticity as a Driver of Immune Escape in Melanoma.Semantic proximity Read ↗

Molecular Susceptibility and Treatment Challenges in Melanoma.Semantic proximity Read ↗

Resistance mechanisms to targeted therapy in BRAF-mutant melanoma - A mini review.Semantic proximity Read ↗

Nongenetic Mechanisms of Drug Resistance in MelanomaSemantic proximity Read ↗

Epigenetic Mechanisms Underlying Melanoma Resistance to Immune and Targeted TherapiesSemantic proximity Read ↗

Emerging targets for combination therapy in melanomasSemantic proximity Read ↗

Advances in Melanoma: From Genetic Insights to Therapeutic InnovationsSemantic proximity Read ↗

Signaling and Immune Regulation in Melanoma Development and Responses to TherapySemantic proximity Read ↗

Genetic and Genomic Pathways of Melanoma Development, Invasion and Metastasis.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.