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The pharmacoepigenomic landscape of cancer cell lines reveals the epigenetic component of drug sensitivity

2023-06-05

Abstract excerpt

Aberrant DNA methylation accompanies genetic alterations during oncogenesis and tumour homeostasis and contributes to the transcriptional deregulation of key signalling pathways in cancer. Despite increasing efforts in DNA methylation profiling of cancer patients, there is still a lack of epigenetic biomarkers to predict treatment efficacy. To address this, we analysed 721 cancer cell lines across 22 cancer types...

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Literature Corpus work
23a5b6df-f967-5392-81ad-805bf247525f
DOI
10.1101/2023.06.01.543264
Open publication

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The pharmacoepigenomic landscape of cancer cell lines reveals the epigenetic component of drug sensitivityDOI 10.1101/2023.06.01.543264
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