Article

Epigenetic modulation reveals differentiation state specificity of oncogene addiction

2020-05-05

Abstract excerpt

Hyperactivation of the MAPK signaling pathway motivates the clinical use of MAPK inhibitors for BRAF-mutant melanomas. Heterogeneity in differentiation state due to epigenetic plasticity, however, results in cell-to-cell variability in the state of MAPK dependency, diminishing the efficacy of MAPK inhibitors. To identify key regulators of such variability, we screened 276 epigenetic-modifying compounds, individual...

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Literature Corpus work: 4d0c8a69-e5b3-5f09-85fc-7a0a2df71895
DOI: 10.1101/2020.05.04.077602

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