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Article

Thapsigargin suppresses alpha 1-acid glycoprotein secretion independently of N-glycosylation and ER stress.

Biochemical and biophysical research communications - 7 May 2021

Goto Nanami, Shibutani Shusaku, Miura Noboru, Watanabe Rie, Iwata Hiroyuki

Abstract excerpt

Alpha-1 acid glycoprotein (AGP) is a major acute-phase protein that is involved in drug/ligand binding and regulation of immune response. In response to inflammation, AGP secretion from the liver increases, resulting in elevated concentration of plasma AGP. AGP exhibits multiple N-glycosylation sites, and thus, is highly glycosylated. Although AGP glycosylation is considered to affect its functions, the...

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PMID: 33740662
DOI: 10.1016/j.bbrc.2021.03.017

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