N-Glycosylation dictates proper processing of organic anion transporting polypeptide 1B1.

doi:10.1371/journal.pone.0052563

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Article

N-Glycosylation dictates proper processing of organic anion transporting polypeptide 1B1.

PloS one - 1 Jan 2012

Yao Juan, Hong Weifang, Huang Jiujiu, Zhan Kai, Huang Hong, Hong Mei

Abstract excerpt

Organic anion transporting polypeptides (OATPs) have been extensively recognized as key determinants of absorption, distribution, metabolism and excretion (ADME) of various drugs, xenobiotics and toxins. Putative N-glycosylation sites located in the extracellular loops 2 and 5 is considered a common feature of all OATPs and some members have been demonstrated to be glycosylated proteins. However, experimental...

Topics

Amino Acid Sequence
Endoplasmic Reticulum
Fluorescent Antibody Technique
Glycosylation
HEK293 Cells
Humans
Liver-Specific Organic Anion Transporter 1
Molecular Sequence Data
Mutant Proteins
Mutation
Organic Anion Transporters
Protein Processing, Post-Translational
Protein Structure, Secondary

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Identifiers

PMID: 23285087
DOI: 10.1371/journal.pone.0052563
PMCID: PMC3527552

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