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Article

Underglycosylation of ATF6 as a novel sensing mechanism for activation of the unfolded protein response.

The Journal of biological chemistry - 19 Mar 2004

Hong Min, Luo Shengzhan, Baumeister Peter, Huang Jen-Ming, Gogia Raveen K, Li Mingqing, Lee Amy S

Abstract excerpt

ATF6 is a key transcriptional activator of the unfolded protein response (UPR), which allows mammalian cells to maintain cellular homeostasis when they are subjected to a variety of environmental and physiological stresses that target the endoplasmic reticulum (ER). ATF6, a 90-kDa ER transmembrane protein, contains three evolutionarily conserved N-linked glycosylation sites within its carboxyl luminal domain....

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Source

Identifiers

PMID: 14699159
DOI: 10.1074/jbc.M309804200

Genes

ATF6

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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Underglycosylation of ATF6 as a novel sensing mechanism for activation of the unfolded protein response.PMID 14699159Read ↗

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