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Article

HDLs protect pancreatic β-cells against ER stress by restoring protein folding and trafficking.

Diabetes - 1 May 2012

Pétremand Jannick, Puyal Julien, Chatton Jean-Yves, Duprez Jessica, Allagnat Florent, Frias Miguel, James Richard W, Waeber Gérard, Jonas Jean-Christophe, Widmann Christian

Abstract excerpt

Endoplasmic reticulum (ER) homeostasis alteration contributes to pancreatic β-cell dysfunction and death and favors the development of diabetes. In this study, we demonstrate that HDLs protect β-cells against ER stress induced by thapsigargin, cyclopiazonic acid, palmitate, insulin overexpression, and high glucose concentrations. ER stress marker induction and ER morphology disruption mediated by these stimuli...

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Share to Endoplasmic Reticulum
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Stress, Physiological

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Identifiers

PMID: 22399686
DOI: 10.2337/db11-1221
PMCID: PMC3331764

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