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Article

Galpha12 regulates protein interactions within the MDCK cell tight junction and inhibits tight-junction assembly.

Journal of cell science - 15 Mar 2008

Sabath Ernesto, Negoro Hideyuki, Beaudry Sarah, Paniagua Manuel, Angelow Susanne, Shah Jagesh, Grammatikakis Nicholas, Yu Alan S L, Denker Bradley M

Abstract excerpt

The polarized functions of epithelia require an intact tight junction (TJ) to restrict paracellular movement and to separate membrane proteins into specific domains. TJs contain scaffolding, integral membrane and signaling proteins, but the mechanisms that regulate TJs and their assembly are not well defined. Galpha12 (GNA12) binds the TJ protein ZO-1 (TJP1), and Galpha12 activates Src to increase paracellular...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to GTP-Binding Protein alpha Subunits, G12-G13

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Source

Identifiers

PMID: 18285450
DOI: 10.1242/jcs.014878

Genes

TPR
GNA12
TJP1
TJP2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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