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Article

Critical role of N-terminal N-glycosylation for proper folding of the human formyl peptide receptor.

Biochemical and biophysical research communications - 14 Feb 2003

Wenzel-Seifert Katharina, Seifert Roland

Abstract excerpt

The human formyl peptide receptor (FPR) is N-glycosylated and activates phagocytes via G(i)-proteins. The FPR expressed with G(i)alpha(2)beta(1)gamma(2) in Sf9 insect cells exhibits high constitutive activity as assessed by strong inhibitory effects of an inverse agonist and Na(+) on basal guanosine 5(')-O-(3-thiotriphosphate) (GTPgammaS) binding. The aim of our study was to analyze the role of N-glycosylation in...

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Identifiers

PMID: 12565836
DOI: 10.1016/s0006-291x(03)00023-8

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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