Article
N-glycosylation is essential for ileal ASBT function and protection against proteases.
American journal of physiology. Cell physiology - 15 Jun 2015
Muthusamy Saminathan, Malhotra Pooja, Hosameddin Mobashir, Dudeja Amish K, Borthakur Sujata, Saksena Seema, Gill Ravinder K, Dudeja Pradeep K, Alrefai Waddah A
Abstract excerpt
The bile acid transporter ASBT is a glycoprotein responsible for active absorption of bile acids. Inhibiting ASBT function and bile acid absorption is an attractive approach to lower plasma cholesterol and improve glucose imbalance in diabetic patients. Deglycosylation of ASBT was shown to decrease its function. However, the exact roles of N-glycosylation of ASBT, and how it affects its function, is not known....
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