Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Soluble GARP has potent antiinflammatory and immunomodulatory impact on human CD4+ T cells

2 Jul 2013

Abstract excerpt

Glycoprotein A repetitions predominant (GARP) is expressed on the surface of activated human regulatory T cells (Treg) and regulates the bioavailability of transforming growth factor-β (TGF-β). GARP has been assumed to require membrane anchoring. To investigate the function of GARP in more detail, we generated a soluble GARP protein (sGARP) and analyzed its impact on differentiation and activation of human CD4⁺ T...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Immune Cell Function and Interaction
Share to PARP inhibition in cancer therapy
Share to T-cell and B-cell Immunology

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 23818544
DOI: 10.1182/blood-2012-12-474478

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Soluble GARP has potent antiinflammatory and immunomodulatory impact on human CD4+ T cellsPMID 23818544Read ↗

Monoclonal antibodies against GARP/TGF-β1 complexes inhibit the immunosuppressive activity of human regulatory T cells in vivoSemantic proximity Read ↗

GARP: a surface molecule of regulatory T cells that is involved in the regulatory function and TGF-β releasingSemantic proximity Read ↗

B lymphocytes confer immune tolerance via cell surface GARP-TGF-β complexSemantic proximity Read ↗

GARP: a key receptor controlling FOXP3 in human regulatory T cells.Semantic proximity Read ↗

GARP regulates the bioavailability and activation of TGFβ.Semantic proximity Read ↗

Human CD4 + HLA‐G + regulatory T cells are potent suppressors of graft‐versus‐host disease in vivoSemantic proximity Read ↗

Characterization of protective human CD4CD25 FOXP3 regulatory T cells generated with IL-2, TGF-β and retinoic acid.Semantic proximity Read ↗

Modulation of the CD4+ T-Cell Response by Helicobacter pylori Depends on Known Virulence Factors and Bacterial Cholesterol and Cholesterol α-Glucoside ContentSemantic proximity Read ↗

Gene expression analysis reveals functional pathways of glatiramer acetate activationSemantic proximity Read ↗

The GARP/Latent TGF-β1 complex on Treg cells modulates the induction of peripherally derived Treg cells during oral tolerance.Semantic proximity Read ↗

Expansion of Functional Regulatory T Cells Using Soluble RAGE Prevents Type 1 DiabetesSemantic proximity Read ↗

CD4+ CD25+ GARP+ regulatory T cells display a compromised suppressive function in patients with dilated cardiomyopathy.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.