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Article

N-glycan-dependent cell-surface expression of the P2Y2 receptor and N-glycan-independent distribution to lipid rafts.

Biochemical and biophysical research communications - 1 Apr 2017

Nakagawa Tetsuto, Takahashi Chihiro, Matsuzaki Hitomi, Takeyama Shohei, Sato Shinpei, Sato Ayaka, Kuroda Yoshiyuki, Higashi Hideyoshi

Abstract excerpt

P2Y2 receptor (P2Y2R) is a G-protein-coupled receptor (GPCR) that couples with Gαq/11 and is stimulated by ATP and UTP. P2Y2R is involved in pain, proinflammatory changes, and blood pressure control. Some GPCRs are localized in lipid rafts for interaction with other signaling molecules. In this study, we prepared N-glycan-deficient mutants by mutating the two consensus Asn residues for N-glycosylation to Gln to...

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PMID: 28209512
DOI: 10.1016/j.bbrc.2017.02.061

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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