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Article

HFE H63D Limits Nigral Vulnerability to Paraquat in Agricultural Workers.

Toxicological sciences : an official journal of the Society of Toxicology - 27 Apr 2021

Wang Ernest W, Trojano Max L, Lewis Mechelle M, Du Guangwei, Chen Hairong, Brown Gregory L, Jellen Leslie C, Song Insung, Neely Elizabeth, Kong Lan, Connor James R, Huang Xuemei

Abstract excerpt

Paraquat is an herbicide whose use is associated with Parkinson's disease (PD), a neurodegenerative disorder marked by neuron loss in the substantia nigra pars compacta (SNc). We recently observed that the murine homolog to the human H63D variant of the homeostatic iron regulator (HFE) may decrease paraquat-associated nigral neurotoxicity in mice. The present study examined the potential influence of H63D on...

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Identifiers

PMID: 33739421
DOI: 10.1093/toxsci/kfab020
PMCID: PMC8081021

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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