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Article

Genetic dissection of strain dependent paraquat-induced neurodegeneration in the substantia nigra pars compacta.

PloS one - 1 Jan 2012

Jiao Yun, Lu Lu, Williams Robert W, Smeyne Richard J

Abstract excerpt

The etiology of the vast majority of Parkinson's disease (PD) cases is unknown. It is generally accepted that there is an interaction between exposures to environmental agents with underlying genetic sensitivity. Recent epidemiological studies have shown that people living in agricultural communities have an increased risk of PD. Within these communities, paraquat (PQ) is one of the most utilized herbicides. PQ...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 22291891
DOI: 10.1371/journal.pone.0029447
PMCID: PMC3265472

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