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Article

Age-related irreversible progressive nigrostriatal dopaminergic neurotoxicity in the paraquat and maneb model of the Parkinson's disease phenotype.

The European journal of neuroscience - 1 Aug 2003

Thiruchelvam Mona, McCormack Alison, Richfield Eric K, Baggs Raymond B, Tank A William, Di Monte Donato A, Cory-Slechta Deborah A

Abstract excerpt

While advancing age is the only unequivocally accepted risk factor for idiopathic Parkinson's disease, it has been postulated that exposure to environmental neurotoxicants combined with ageing could increase the risk for developing Parkinson's disease. The current study tested this hypothesis by exposing C57BL/6 mice that were 6 weeks, 5 months or 18 months old to the herbicide paraquat, the fungicide maneb or...

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Identifiers

PMID: 12911755
DOI: 10.1046/j.1460-9568.2003.02781.x

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