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Article

Unique nigral and cortical pathways implicated by epigenomic and transcriptional analyses in rotenone Parkinson’s model

24 Jul 2025

Abstract excerpt

Pesticide exposure is increasingly recognized as a potential environmental factor in idiopathic Parkinson's disease, though the molecular mechanisms remain unclear. This study explores how pesticide exposure alters gene regulation in key brain regions using the rotenone rat model. We performed H3K27ac ChIP-sequencing to profile active regulatory elements in the substantia nigra and motor cortex. Despite uniform...

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PMID: 40707475
DOI: 10.1038/s41531-025-01049-1

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