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Article

Genetic-based, differential susceptibility to paraquat neurotoxicity in mice.

Neurotoxicology and teratology - 1 Jan 2000

Yin Lina, Lu Lu, Prasad Kavita, Richfield Eric K, Unger Erica L, Xu Jialin, Jones Byron C

Abstract excerpt

Paraquat (PQ) is an herbicide used extensively in agriculture. This agent is also suspected to be a risk factor for Parkinson's disease (PD) by harming nigro-striatal dopamine neurons. There is likely, genetic-based, individual variability in susceptibility to PQ neurotoxicity related PD. In this study, we measured the delivery of PQ to the brain after three weekly injections of PQ at 5 mg kg(-1), PQ-related...

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Identifiers

PMID: 21371552
DOI: 10.1016/j.ntt.2011.02.012

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