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Article

Is a rare CXCL8 gene variant a new possible cause or course factor of inflammatory bowel disease?

19 Mar 2025

Abstract excerpt

Introduction The pathogenesis of inflammatory bowel diseases (IBD) involves genetic, environmental, immunological, and microbial factors; however, it remains unclear. Pro-inflammatory interleukin 8 (IL-8), encoded by the CXCL8 gene, assumes a crucial chemotactic role in leukocyte migration. Methods This study aimed to investigate whether an association exists between IBD and two CXCL8 variants, namely, c.-251A>T...

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PMID: 40176809
DOI: 10.3389/fimmu.2025.1562618

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