Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Effect of Leptin Receptor Q223R Polymorphism on Clostridioides difficile Infection-Induced Macrophage Migration Inhibitory Factor Production.

The Journal of infectious diseases - 16 Oct 2024

Mathew Ann M, Huber Alexander, Sous Rowis D, Weghorn Kristin N, Powers-Fletcher Margaret V, Jose Shinsmon, Madan Rajat

Abstract excerpt

Proinflammatory cytokine levels and host genetic makeup are key determinants of Clostridioides difficile infection (CDI) outcomes. We previously reported that blocking the inflammatory cytokine macrophage migration inhibitory factor (MIF) ameliorates CDI. Here, we determined kinetics of MIF production and its association with a common genetic variant in leptin receptor (LEPR) using blood from patients with CDI....

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Aged
Share to Clostridioides difficile

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Clostridium Infections

Share to Genotype

Share to Intramolecular Oxidoreductases

Share to Macrophage Migration-Inhibitory Factors

Share to Polymorphism, Single Nucleotide

Share to Receptors, Leptin

Source

Open in PubMed Open full text

Identifiers

PMID: 38687212
DOI: 10.1093/infdis/jiae141
PMCID: PMC11481448

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Effect of Leptin Receptor Q223R Polymorphism on Clostridioides difficile Infection-Induced Macrophage Migration Inhibitory Factor Production.PMID 38687212Read ↗

Leptin Receptor q223r Polymorphism Influences Clostridioides difficile Infection-Induced Neutrophil CXCR2 Expression in an Interleukin-1β Dependent Manner.Semantic proximity Read ↗

Leptin receptor q223r polymorphism influences neutrophil mobilization after Clostridium difficile infection.Semantic proximity Read ↗

Role of leptin-mediated colonic inflammation in defense against Clostridium difficile colitis.Semantic proximity Read ↗

The presence of IL-8 +781 T/C polymorphism is associated with the parameters of severe Clostridium difficile infection.Semantic proximity Read ↗

Macrophage migration inhibitory factor: gene polymorphisms and susceptibility to inflammatory diseases.Semantic proximity Read ↗

Macrophage migration inhibitory factor (MIF): a promising biomarker.Semantic proximity Read ↗

Effect of the leptin receptor Q223R polymorphism on the host transcriptome following infection with Entamoeba histolytica.Semantic proximity Read ↗

Functional polymorphisms in the gene encoding macrophage migration inhibitory factor are associated with Gram-negative bacteremia in older adults.Semantic proximity Read ↗

Macrophage migration inhibitory factor (MIF) -173G/C promoter polymorphism influences upper gastrointestinal tract involvement and disease activity in patients with Crohn's disease.Semantic proximity Read ↗

Serum mannose-binding lectin concentration, but not genotype, is associated with Clostridium difficile infection recurrence: a prospective cohort study.Semantic proximity Read ↗

Leptin Receptor Mutation Results in Defective Neutrophil Recruitment to the Colon during Entamoeba histolytica InfectionSemantic proximity Read ↗

Single nucleotide polymorphisms in the promoter of the gene encoding the lipopolysaccharide receptor CD14 are associated with bacterial diarrhea in US and Canadian travelers to Mexico.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.