Article
Cxcr2 and Cxcl5 regulate the IL-17/G-CSF axis and neutrophil homeostasis in mice.
The Journal of clinical investigation - 1 Mar 2012
Mei Junjie, Liu Yuhong, Dai Ning, Hoffmann Christian, Hudock Kristin M, Zhang Peggy, Guttentag Susan H, Kolls Jay K, Oliver Paula M, Bushman Frederic D, Worthen G Scott
Abstract excerpt
Neutrophils are essential for maintaining innate immune surveillance under normal conditions, but also represent a major contributor to tissue damage during inflammation. Neutrophil homeostasis is therefore tightly regulated. Cxcr2 plays a critical role in neutrophil homeostasis, as Cxcr2(-/-) mice demonstrate mild neutrophilia and severe neutrophil hyperplasia in the bone marrow. The mechanisms underlying these...
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