Article
Role of leptin-mediated colonic inflammation in defense against Clostridium difficile colitis.
Infection and immunity - 1 Jan 2014
Madan Rajat, Guo Xiaoti, Naylor Caitlin, Buonomo Erica L, Mackay Donald, Noor Zannatun, Concannon Patrick, Scully Kenneth W, Pramoonjago Patcharin, Kolling Glynis L, Warren Cirle A, Duggal Priya, Petri William A
Abstract excerpt
The role of leptin in the mucosal immune response to Clostridium difficile colitis, a leading cause of nosocomial infection, was studied in humans and in a murine model. Previously, a mutation in the receptor for leptin (LEPR) was shown to be associated with susceptibility to infectious colitis and liver abscess due to Entamoeba histolytica as well as to bacterial peritonitis. Here we discovered that European...
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