Leptin Receptor Mutation Results in Defective Neutrophil Recruitment to the Colon during Entamoeba histolytica Infection

Abstract excerpt

UNLABELLED: Amebiasis is an enteric infection caused by Entamoeba histolytica, with symptoms ranging in severity from asymptomatic colonization to dysentery. Humans with the Q223R leptin receptor mutation have increased susceptibility to amebiasis, but the mechanism has been unclear. Using a mouse model expressing the mutation, we tested the impact of the Q223R mutation on the innate immune response to E....

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Amoebic Infections and Treatments
• Share to Immune Response and Inflammation
• Share to Neonatal and Maternal Infections