Clinical, environmental, and genetic determinants of multiple sclerosis in children with acute demyelination: a prospective national cohort study.

doi:10.1016/S1474-4422(11)70045-X

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Article

Clinical, environmental, and genetic determinants of multiple sclerosis in children with acute demyelination: a prospective national cohort study.

The Lancet. Neurology - 1 May 2011

Banwell Brenda, Bar-Or Amit, Arnold Douglas L, Sadovnick Dessa, Narayanan Sridar, McGowan Melissa, O'Mahony Julia, Magalhaes Sandra, Hanwell Heather, Vieth Reinhold, Tellier Raymond, Vincent Thierry, Disanto Giulio, Ebers George, Wambera Katherine, Connolly Mary B, Yager Jerome, Mah Jean K, Booth Fran, Sebire Guillaume, Callen David, Meaney Brandon, Dilenge Marie-Emmanuelle, Lortie Anne, Pohl Daniela, Doja Asif, Venketaswaran Sunita, Levin Simon, Macdonald E Athen, Meek David, Wood Ellen, Lowry Noel, Buckley David, Yim Conrad, Awuku Mark, Cooper Pamela, Grand'maison François, Baird J Burke, Bhan Virender, Marrie Ruth Ann

Abstract excerpt

BACKGROUND: HLA-DRB1*15 genotype, previous infection with Epstein-Barr virus, and vitamin D insufficiency are susceptibility factors for multiple sclerosis, but whether they act synergistically to increase risk is unknown. We aimed to assess the contributions of these risk factors and the effect of established precursors of multiple sclerosis, such as brain lesions on MRI and oligoclonal bands in CSF at the time...

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PMID: 21459044
DOI: 10.1016/S1474-4422(11)70045-X

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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