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Article

Gene-Environment Interactions in Multiple Sclerosis: A UK Biobank Study.

Neurology(R) neuroimmunology & neuroinflammation - 1 Jul 2021

Jacobs Benjamin Meir, Noyce Alastair J, Bestwick Jonathan, Belete Daniel, Giovannoni Gavin, Dobson Ruth

Abstract excerpt

OBJECTIVE: We sought to determine whether genetic risk modifies the effect of environmental risk factors for multiple sclerosis (MS). To test this hypothesis, we tested for statistical interaction between polygenic risk scores (PRS) capturing genetic susceptibility to MS and environmental risk factors for MS in UK Biobank. METHODS: People with MS were identified within UK Biobank using ICD-10-coded MS or...

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Identifiers

PMID: 34049995
DOI: 10.1212/NXI.0000000000001007
PMCID: PMC8192056

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