Article
Interactions between genetic, lifestyle and environmental risk factors for multiple sclerosis.
Nature reviews. Neurology - 1 Jan 2017
Olsson Tomas, Barcellos Lisa F, Alfredsson Lars
Abstract excerpt
Genetic predisposition to multiple sclerosis (MS) only explains a fraction of the disease risk; lifestyle and environmental factors are key contributors to the risk of MS. Importantly, these nongenetic factors can influence pathogenetic pathways, and some of them can be modified. Besides established MS-associated risk factors - high latitude, female sex, smoking, low vitamin D levels caused by insufficient sun...
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