Article
Interaction between passive smoking and two HLA genes with regard to multiple sclerosis risk.
International journal of epidemiology - 1 Dec 2014
Hedström Anna Karin, Bomfim Izaura Lima, Barcellos Lisa F, Briggs Farren, Schaefer Catherine, Kockum Ingrid, Olsson Tomas, Alfredsson Lars
Abstract excerpt
BACKGROUND: The recently described interaction between smoking, human leukocyte antigen (HLA) DRB1*15 and absence of HLA-A*02 with regard to multiple sclerosis (MS) risk shows that the risk conveyed by smoking differs depending on genetic background. We aimed to investigate whether a similar interaction exists between passive smoking and HLA genotype. METHODS: We used one case-control study with incident cases of...
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