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Article

Interaction between smoking and HLA-A*02:01 in multiple sclerosis progression.

Multiple sclerosis (Houndmills, Basingstoke, England) - 1 Aug 2026

Hedström Anna Karin, Stridh Pernilla, Hillert Jan, Olsson Tomas, Alfredsson Lars

Abstract excerpt

BACKGROUND: Gene-environment interactions between smoking and HLA genotypes have been reported in multiple sclerosis (MS) susceptibility, although their relevance beyond disease onset remains unclear. OBJECTIVES: To examine whether the effect of smoking on disability progression differs according to HLA-A*02:01 and HLA-DRB1*15:01 status. METHODS: Patients from two population-based case-control cohorts were...

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Identifiers

PMID: 42397838
DOI: 10.1177/13524585261453243
PMCID: PMC13385633

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