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Differentiation dynamics of mammary epithelial cells revealed by single-cell RNA sequencing

8 Dec 2017

Abstract excerpt

Characterising the hierarchy of mammary epithelial cells (MECs) and how they are regulated during adult development is important for understanding how breast cancer arises. Here we report the use of single-cell RNA sequencing to determine the gene expression profile of MECs across four developmental stages; nulliparous, mid gestation, lactation and post involution. Our analysis of 23,184 cells identifies 15...

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PMID: 29225342
DOI: 10.1038/s41467-017-02001-5

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