Article

Spatiotemporal organisation of residual disease in mouse and human BRCA1-deficient mammary tumours and breast cancer

2025-04-03

Abstract excerpt

Breast cancer remains one of the prominent causes of death worldwide. Although chemotherapeutic agents often result in substantial reduction of primary or metastatic tumours, remaining drug-tolerant tumour cell populations, known as minimal residual disease (MRD), pose a significant risk of recurrence and therapy resistance. In this study, we describe the spatiotemporal organisation of therapy response and MRD in...

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Literature Corpus work: 1e41406f-60ef-52a0-ab9e-5b9c6f571ca1
DOI: 10.1101/2025.04.02.646768

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