Article
BRCA1 basal-like breast cancers originate from luminal epithelial progenitors and not from basal stem cells.
Cell stem cell - 3 Sept 2010
Molyneux Gemma, Geyer Felipe C, Magnay Fiona-Ann, McCarthy Afshan, Kendrick Howard, Natrajan Rachael, Mackay Alan, Grigoriadis Anita, Tutt Andrew, Ashworth Alan, Reis-Filho Jorge S, Smalley Matthew J
Abstract excerpt
Breast cancers in BRCA1 mutation carriers frequently have a distinctive basal-like phenotype. It has been suggested that this results from an origin in basal breast epithelial stem cells. Here, we demonstrate that deleting Brca1 in mouse mammary epithelial luminal progenitors produces tumors that phenocopy human BRCA1 breast cancers. They also resemble the majority of sporadic basal-like breast tumors. However,...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.