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Pancancer analysis of DNA damage repair gene mutations and their impact on immune regulatory gene expression

5 May 2025

Abstract excerpt

DNA damage is a key factor in many human disorders, including cancer, chronic inflammation, and early aging. Genes involved in DNA damage repair (DDR) not only maintain genomic stability but also contribute to immune responses by regulating the expression of antimicrobial peptides and ligands that activate immune receptors. Various components of the DNA damage response (DDR), including DNA damage sensors,...

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PMID: 40325163
DOI: 10.1038/s41598-025-99965-y

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