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Article

Alterations in DNA damage response and repair genes as potential biomarkers for immune checkpoint blockade in gastrointestinal cancer.

Cancer biology & medicine - 28 Sept 2021

Wang Yujiao, Jiao Xi, Li Shuang, Chen Huan, Wei Xin, Liu Chang, Gong Jifang, Zhang Xiaotian, Wang Xicheng, Peng Zhi, Qi Changsong, Wang Zhenghang, Wang Yanni, Zhuo Na, Zou Jianling, Zhang Henghui, Li Jian, Shen Lin, Lu Zhihao

Abstract excerpt

OBJECTIVE: Immune checkpoint inhibitors (ICIs) have achieved remarkable results in cancer treatments. However, there is no effective predictive biomarker for gastrointestinal (GI) cancer. METHODS: We conducted integrative analyses of the genomic and survival data of ICI-treated GI cancer patients from the Memorial Sloan Kettering Cancer Center cohort (MSK-GI, n = 227), the Janjigian cohort (n = 40), and the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 34570439
DOI: 10.20892/j.issn.2095-3941.2020.0708
PMCID: PMC9425187

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