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Article

Germline DNA damage response gene mutations as predictive biomarkers of immune checkpoint inhibitor efficacy.

Frontiers in immunology - 1 Jan 2024

Dennis Michael J, Bylsma Sophia, Madlensky Lisa, Pagadala Meghana S, Carter Hannah, Patel Sandip P

Abstract excerpt

Background: Impaired DNA damage response (DDR) can affect immune checkpoint inhibitors (ICI) efficacy and lead to heightened immune activation. We assessed the impact of pathogenic or likely pathogenic (P/LP) germline DDR mutations on ICI response and toxicity. Materials and methods: A retrospective analysis of 131 cancer patients with germline DNA testing and ICI treatment was performed. Results: Ninety-two...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 38348036
DOI: 10.3389/fimmu.2024.1322187
PMCID: PMC10859432

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