Article
Atlas of the clinical genetics of human dilated cardiomyopathy.
European heart journal - 7 May 2015
Haas Jan, Frese Karen S, Peil Barbara, Kloos Wanda, Keller Andreas, Nietsch Rouven, Feng Zhu, Müller Sabine, Kayvanpour Elham, Vogel Britta, Sedaghat-Hamedani Farbod, Lim Wei-Keat, Zhao Xiaohong, Fradkin Dmitriy, Köhler Doreen, Fischer Simon, Franke Jennifer, Marquart Sabine, Barb Ioana, Li Daniel Tian, Amr Ali, Ehlermann Philipp, Mereles Derliz, Weis Tanja, Hassel Sarah, Kremer Andreas, King Vanessa, Wirsz Emil, Isnard Richard, Komajda Michel, Serio Alessandra, Grasso Maurizia, Syrris Petros, Wicks Eleanor, Plagnol Vincent, Lopes Luis, Gadgaard Tenna, Eiskjær Hans, Jørgensen Mads, Garcia-Giustiniani Diego, Ortiz-Genga Martin, Crespo-Leiro Maria G, Deprez Rondal H Lekanne Dit, Christiaans Imke, van Rijsingen Ingrid A, Wilde Arthur A, Waldenstrom Anders, Bolognesi Martino, Bellazzi Riccardo, Mörner Stellan, Bermejo Justo Lorenzo, Monserrat Lorenzo, Villard Eric, Mogensen Jens, Pinto Yigal M, Charron Philippe, Elliott Perry, Arbustini Eloisa, Katus Hugo A, Meder Benjamin
Abstract excerpt
AIM: Numerous genes are known to cause dilated cardiomyopathy (DCM). However, until now technological limitations have hindered elucidation of the contribution of all clinically relevant disease genes to DCM phenotypes in larger cohorts. We now utilized next-generation sequencing to overcome these limitations and screened all DCM disease genes in a large cohort. METHODS AND RESULTS: In this multi-centre,...
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