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Article

Inherently confinable split-drive systems in Drosophila.

Nature communications - 5 Mar 2021

Terradas Gerard, Buchman Anna B, Bennett Jared B, Shriner Isaiah, Marshall John M, Akbari Omar S, Bier Ethan

Abstract excerpt

CRISPR-based gene-drive systems, which copy themselves via gene conversion mediated by the homology-directed repair (HDR) pathway, have the potential to revolutionize vector control. However, mutant alleles generated by the competing non-homologous end-joining (NHEJ) pathway, resistant to Cas9 cleavage, can interrupt the spread of gene-drive elements. We hypothesized that drives targeting genes essential for...

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Source

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Identifiers

PMID: 33674604
DOI: 10.1038/s41467-021-21771-7
PMCID: PMC7935863

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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