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Article

A mammalian functional-genetic approach to characterizing cancer therapeutics.

Nature chemical biology - 1 Feb 2011

Jiang Hai, Pritchard Justin R, Williams Richard T, Lauffenburger Douglas A, Hemann Michael T

Abstract excerpt

Identifying mechanisms of drug action remains a fundamental impediment to the development and effective use of chemotherapeutics. Here we describe an RNA interference (RNAi)-based strategy to characterize small-molecule function in mammalian cells. By examining the response of cells expressing short hairpin RNAs (shRNAs) to a diverse selection of chemotherapeutics, we could generate a functional shRNA signature...

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PMID: 21186347
DOI: 10.1038/nchembio.503
PMCID: PMC3070540

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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