Article
Hepatitis B Virus Infection Among Leprosy Patients: A Case for Polymorphisms Compromising Activation of the Lectin Pathway and Complement Receptors.
Frontiers in immunology - 1 Jan 2020
Boldt Angelica Beate Winter, Oliveira-Toré Camila de Freitas, Kretzschmar Gabriela Canalli, Weinschutz Mendes Hellen, Stinghen Sérvio Túlio, Andrade Fabiana Antunes, Bumiller-Bini Valéria, Gonçalves Letícia Boslooper, Braga Anna Carolina de Moraes, Stahlke Ewalda von Rosen Seeling, Velavan Thirumalaisamy P, Thiel Steffen, de Messias-Reason Iara José Taborda
Abstract excerpt
Thousands of leprosy patients not only suffer from physical deformities, but also either have or have had hepatitis B virus (HBV) coinfection. Polymorphisms of the complement system modulate susceptibility to leprosy, but genetic susceptibility to past or present HBV infection is unknown. We used sequencing and multiplex sequence-specific PCR to genotype 72 polymorphisms of seven genes (MBL2, FCN1, FCN2, FCN3,...
Topics
- Adult
- Aged
- Aged, 80 and over
- Coinfection
- Complement Pathway, Mannose-Binding Lectin
- Complement System Proteins
- Female
- Genetic Association Studies