Adding MASP1 to the lectin pathway-Leprosy association puzzle: Hints from gene polymorphisms and protein levels.

doi:10.1371/journal.pntd.0007534

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Article

Adding MASP1 to the lectin pathway-Leprosy association puzzle: Hints from gene polymorphisms and protein levels.

PLoS neglected tropical diseases - 1 Apr 2020

Weinschutz Mendes Hellen, Boldt Angelica Beate Winter, von Rosen Seeling Stahlke Ewalda, Jensenius Jens Christian, Thiel Steffen, Messias-Reason Iara J Taborda

Abstract excerpt

BACKGROUND: Deposition of complement factors on Mycobacterium leprae may enhance phagocytosis. Such deposition may occur through the lectin pathway of complement. Three proteins of the lectin pathway are produced from the gene MASP1: Mannan-binding lectin-associated serine protease 1 (MASP-1) and MASP-3 and mannan-binding lectin-associated protein of 44 kDa (MAp44). Despite their obvious importance, the roles...

Topics

Adolescent
Adult
Aged
Aged, 80 and over
Case-Control Studies
Cross-Sectional Studies
Female
Genetic Predisposition to Disease
Haplotypes
Humans

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Leprosy

Male

Mannose-Binding Protein-Associated Serine Proteases

Middle Aged

Mycobacterium leprae

Polymorphism, Single Nucleotide

Young Adult

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Identifiers

PMID: 32240160
DOI: 10.1371/journal.pntd.0007534
PMCID: PMC7162614

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