Complement receptor 1 (CR1, CD35) association with susceptibility to leprosy.

doi:10.1371/journal.pntd.0006705

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Article

Complement receptor 1 (CR1, CD35) association with susceptibility to leprosy.

PLoS neglected tropical diseases - 1 Aug 2018

Kretzschmar Gabriela Canalli, Oliveira Luana Caroline, Nisihara Renato Mitsunori, Velavan Thirumalaisamy P, Stinghen Sérvio Túlio, Stahlke Ewalda R S, Petzl-Erler Maria Luiza, Messias-Reason Iara José T de, Boldt Angelica Beate Winter

Abstract excerpt

BACKGROUND: Pathophysiological mechanisms are still incompletely understood for leprosy, an urgent public health issue in Brazil. Complement receptor 1 (CR1) binds complement fragments C3b/C4b deposited on mycobacteria, mediating its entrance in macrophages. We investigated CR1 polymorphisms, gene expression and soluble CR1 levels in a case-control study with Brazilian leprosy patients, aiming to understand the...

Topics

Adolescent
Adult
Aged
Aged, 80 and over
Brazil
Case-Control Studies
Female
Genetic Predisposition to Disease
Haplotypes
Humans
Leprosy
Male
Middle Aged

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Polymorphism, Genetic

Receptors, Complement 3b

Young Adult

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Identifiers

PMID: 30092084
DOI: 10.1371/journal.pntd.0006705
PMCID: PMC6103516

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