Leprosy association with low MASP-2 levels generated by MASP2 haplotypes and polymorphisms flanking MAp19 exon 5.

doi:10.1371/journal.pone.0069054

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Article

Leprosy association with low MASP-2 levels generated by MASP2 haplotypes and polymorphisms flanking MAp19 exon 5.

PloS one - 1 Jan 2013

Boldt Angelica Beate Winter, Goeldner Isabela, Stahlke Ewalda R S, Thiel Steffen, Jensenius Jens Christian, de Messias-Reason Iara José Taborda

Abstract excerpt

BACKGROUND: The gene MASP2 (mannan-binding lectin (MBL)-associated serine protease 2) encodes two proteins, MASP-2 and MAp19 (MBL-associated protein of 19 kDa), bound in plasma to MBL and ficolins. The binding of MBL/MASP-2 and ficolin/MASP-2 complexes to microorganisms activates the lectin pathway of complement and may increase the ingestion of intracellular pathogens such as Mycobacterium leprae. METHODS: We...

Topics

Adolescent
Adult
Aged
Aged, 80 and over
Alleles
Brazil
Disease Progression
Exons
Female
Gene Frequency
Gene Order
Genetic Predisposition to Disease
Haplotypes
Humans

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Leprosy

Male

Mannose-Binding Protein-Associated Serine Proteases

Middle Aged

Source

Open in PubMed Open full text

Identifiers

PMID: 23935922
DOI: 10.1371/journal.pone.0069054
PMCID: PMC3728295

Genes

MASP2

Provenance

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