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Article

Leprosy association with low MASP-2 levels generated by MASP2 haplotypes and polymorphisms flanking MAp19 exon 5.

PloS one - 1 Jan 2013

Boldt Angelica Beate Winter, Goeldner Isabela, Stahlke Ewalda R S, Thiel Steffen, Jensenius Jens Christian, de Messias-Reason Iara José Taborda

Abstract excerpt

BACKGROUND: The gene MASP2 (mannan-binding lectin (MBL)-associated serine protease 2) encodes two proteins, MASP-2 and MAp19 (MBL-associated protein of 19 kDa), bound in plasma to MBL and ficolins. The binding of MBL/MASP-2 and ficolin/MASP-2 complexes to microorganisms activates the lectin pathway of complement and may increase the ingestion of intracellular pathogens such as Mycobacterium leprae. METHODS: We...

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Source

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Identifiers

PMID: 23935922
DOI: 10.1371/journal.pone.0069054
PMCID: PMC3728295

Genes

MASP2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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